Molecular Diagnostics Laboratory

Laboratory Overview

The Molecular Diagnostics Laboratory is operated as a reference laboratory by the Department of Pathology at the University of Texas Health Science Center at San Antonio. The laboratory is involved in teaching medical students, residents, and fellows, and also provides support services for faculty and staff of the Health Science Center, as well as services to outside entities on a fee-for-service basis.

The laboratory develops and performs molecular diagnostic tests for nucleic acid targets found in a variety of settings in medicine. The primary focus of the laboratory is hematopathology; a selection of genetic and infectious disease tests are also performed.

The Molecular Diagnostics Laboratory is fully accredited by and participates in the College of American Pathologists (CAP) inspection and accreditation programs. Through the deemed status granted to the CAP, the laboratory is also accredited by the Health Care Financing Administration through the Clinical Laboratory Improvement Act (CLIA) for the performance of high complexity testing. Current certificates of accreditation may be viewed here: CAP, CLIA.

Request Forms

Molecular Request Form
Paraffin Supplemental Form
PGx Supplemental Form

Specimen Collection

Test Menu

Tests Currently Performed by the Molecular Diagnostics Laboratory

BCR-ABL p210 quantitation by real-time PCR and report on IS
BCR-ABL p190 quantitation by real-time PCR
PML-RARα Translocation t(15;17) by Real-time PCR
BCL2 translocation major breakpoint by real-time PCR
JAK2 mutation (V617F) detection by real-time PCR
IGH clonality detection by PCR and capillary electrophoresis
IG kappa Gene Clonality Detection by PCR and Capillary Electrophoresis
TCR gamma clonality detection by PCR and capillary electrophoresis
TCR beta clonality detection by PCR and capillary electrophoresis

Inherited disease
F5 Leiden (R506Q) mutation by Real-Time PCR
Prothrombin (F2) G20210A mutation by Real-Time PCR
Hemochromatosis (HFE) 2 Mutations

Infectious disease
Molecular identification of fungi (order through the Fungal Testing Laboratory)