RYAN S. ROBETORYE, Ph.D.,M.D.
Assistant Professor. Division of Hematopathology

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Department of Pathology – Mail Code 7750
The University of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio, Texas 78229-3900
INFORMATION
Email: robetorye@uthscsa.edu
Phone: (210) 567-4087   Fax: (210) 567-4819



EDUCATION
1984 BS, Biology, History, PreMedicine.  Kansas State University, Manhattan, KS
1995 Ph.D., Cell Biology, Baylor College of Medicine, Houston TX.
1997 M.D., Baylor College of Medicine, Houston TX
 
POSTDOCTORAL TRAINING
1997-2001 Residency, Department of Pathology,University of Utah Health Sciences Center, Salt Lake City UT
2001-2003 Fellowship, Division of Hematopathology, Department of Pathology, University of Utah Health Sciences Center, Salt Lake City UT
 
DESCRIPTION OF RESEARCH

  My laboratory is interested in identifying novel genes and/or gene pathways involved in non-Hodgkin’s lymphoma development and progression. Using DNA microarray technology, we have identified a previously uncharacterized gene that is consistently down-regulated when clinically indolent follicular lymphomas transform to higher grade diffuse large B-cell lymphomas. We are currently interested in further characterizing the possible role of this gene in lymphomagenesis as well identifying additional genes that play a role in this process. Since non-Hodgkin’s lymphomas are primarily neoplasms of older individuals, we are also interested in determining the influences of aging on the process of lymphomagenesis using an aging mouse lymphoma model. Ultimately, we hope to identify novel genes that could potentially be used as new therapeutic targets for the treatment of non-Hodgkin lymphomas.



SELECTED PUBLICATIONS

1. Elenitoba-Johnson, K. S. J., Mitchell, R. S., Bohling, S. D., Brown, M. S.,  and Robetorye, R. S. (2000). PCR analysis of the immunoglobulin heavy chain gene in polyclonal processes can yield pseudoclonal bands as an artifact of low B cell number. J. Mol. Diag. 2, 92-96.

2. Robetorye, R. S., Bohling, S. D., Medeiros,  L. J., and Elenitoba-Johnson, K. S. J. (2000). Follicular lymphoma with monocytoid  B-cell proliferation:  molecular assessment of the clonal relationship between the follicular and monocytoid B-cell components. Lab. Invest. 80, 1593-1599.

3. Robetorye, R. S., and Rodgers,  G. M. (2001). Update on selected inherited venous thrombotic disorders. Am. J. Hematol. 68, 256-258.

4. Fillmore, G. C., Lin, Z., Bohling, S. D., Robetorye,  R. S., Kim, C.-H., Jenson, S. D., Elenitoba-Johnson, K. S. J., and Lim, M.  S. (2002). Gene  expression profiling of T-cell lymphoma cell lines. FEBS Lett. 522, 183-188.

5. Robetorye,  R. S., Bohling, S. D., Morgan, J. W., Fillmore, G. C., Lim, M. S., and Elenitoba-Johnson,  K. S. J. (2002). Gene expression profiling  of  B-cell lymphoma cell lines with the t(14;18). J. Mol. Diagn. 4, 123-136.

6. Jenson, S. D., Robetorye, R. S., Bohling, S. D., Schumacher, J. S., Morgan,  J. W., Lim, M. S., Elenitoba-Johnson, K. S. J. (2003). Validation  of  cDNA microarray gene expression data obtained from linearly amplified  RNA. Mol. Pathol. 56,  307-312.

Updated on 02/26/2004