GLEN E. MOTT, Ph.D.,
Professor of Pathology and Clinical Laboratory Sciences

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Department of Pathology – Mail Code 7750
The University of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio, Texas 78229-3900
INFORMATION
Email: mott@uthscsa.edu
Phone: (210) 567-4023   Fax: (210) 567-4819


EDUCATION:
1963 B.S., Biochemistry, Purdue University
1967 M.S., Biochemistry, University of Minnesota
1970 Ph.D., Biochemistry & Nutrition, Texas A&M University
 
POSTDOCTORAL TRAINING
1971-73 NIH Postdoctoral Fellow, McArdle Laboratory, University of Wisconsin, Madison
 

DESCRIPTION OF RESEARCH:
   My major research activity is studying the molecular mechanisms of neonatal dietary imprinting of cholesterol metabolism later in life. In recent years, we have identified long-term differences in lipoprotein concentrations, cholesterol and bile acid metabolism, and in thyroid hormone homeostasis due to breast- vs formula feeding. These studies include kinetic measurements of cholesterol and bile acid turnover in primates, and assays for rate limiting processes in hepatic cholesterol synthesis and degradation and measurements of plasma lipid and lipoprotein measurements. To characterize the metabolic basis of the deferred dietary effects we also determine rate limiting enzymes in cholesterol biosynthesis and degradation such as HMG-CoA reductase, cholesterol 26-hydroxylase, cholesterol 7a-hydroxylase, 26-hydroxycholesterol 7a-hydroxylase and enzymes involved in cholesterol esterification. We also measure hepatic mRNA concentrations for the some of the key regulatory steps in cholesterol metabolism.
   Other interests include genetic effects on cholesterol metabolism and the role of dietary cholesterol and type of fat in atherogenesis. We also have done preliminary studies on the oxidation of lipids in relation to periodontal disease and the possible link to atherosclerosis.

CLINICAL:
   Medical Director of Chemistry, Pathology Laboratories, University Hospital, San Antonio, TX

SELECTED PUBLICATIONS:

1. Mott, G.E., Jackson, E.M., DeLallo, L., Lewis, D.S., and McMahan, C.A. Differences in cholesterol metabolism in juvenile baboons are programmed by breast- vs. formula-feeding. J. Lipid Res. 36:299-307, 1995.

2. Lewis, D.S., Jackson, E.M., and Mott, G.E. Triiodothyronine accelerates maturation of bile acid metabolism in infant baboons. Am. J. Physiol. 268:E889-E896, 1995.

3. McGill, H.C., Mott, G.E., Lewis, D.S., McMahan, C.A., and Jackson, E.M. Early determinants of adult metabolic regulation: Effects of infant nutrition on adult lipid and lipoprotein metabolism. Nutr. Rev. 54:S31-S40, 1996.

4. Mott, G.E., Lewis, D.S., Jackson, E.M., and McMahan, C.A. Preweaning diet programs postweaning plasma thyroxine concentrations in baboons. Proc. Soc. Exptl. Biol. Med. 212:342-348, 1996.

5. Mott, G.E. Early feeding and atherosclerosis. IN: Long Term Consequences of Early Feeding, Rey J, Laron Z, and Boulton J (eds), Nestle Nutrition Workshop Ser., Vol. 36, Nestle Nutrition, Vevey/Raven Press, New York, pp. 113-122, 1996

6. Ghosh, P.M., Mott, G.E., Ghosh-Choudhury, N., Radnik, R.A., Stapleton, M.L., Ghidoni, J.J., and Kreisberg, J.I. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochim. Biophys. Acta. 1359:13-24, 1997.

7. Mott, G.E. Developmental Physiology of Serum Cholesterol and Lipoprotein Concentrations. IN: Fetal and Neonatal Physiology, R.A. Polin and W.W. Fox (eds), W.B. Saunders, Philadelphia, 1998.

8. Mott, G.E. Early Feeding and Atherosclerosis. IN: Long Term Consequences of Early Feeding, Alan Lucas (ed), Proc. IVth Sodilac Nutrition Symposium, Sodilac Nutritional Seminar Series, John Libbey Eurotext, Paris, pp. 17-25, 1999

9. Ghosh, P.M., Moyer, M., Mott, G.E. and Kreisberg, J.I. Over expression of cyclin E inhibits lovastatin induced cell rounding/growth arrest. J. Cell. Biochem. 74(4):532-43, 1999.

10.Mahaney, M.C., Blangero, J., Rainwater, D.L., Mott, G.E., Comuzzie, A.G., MacCluer, J.W., VandeBerg, J.L. Pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of HDL subffractions in two dietary environments. Arterioscler. Thromb. & Vasc. Biol. 19(4):1134-41, 1999.

11.Lewis, D.S., Oren, S., Wang, X., Moyer, M., Beitz, D., Knight, T.J., Mott, G.E. Developmental changes in cholesterol 7a- and 27-hydroxylases in the piglet. J. Anim. Sci. 78: 943-951, 2000.

12.Li, S., Pang, J., Jackson, E.M., Wilson, W.K., Mott, G.E., Schroepfer, G.J. Jr. Kinetics and plasma concentrations of 26-hydroxycholesterol in baboons. Biochim. Biophys. Acta. 1458: 173-184, 2000.

13.Kemnitz, J.W., Sapolski, R.M., Altmann, J., Muruthi, P., Mott, G.E., Stefanick, M. Effects of food availability on serum insulin and lipid concentrations in free-ranging baboons. Am. J. Primatol. 57:13-19, 2002

14.Mott, G. E., Jackson, E. M., Klein, M. L., Shan, H., Pang, J., Wilson, W. K., McMahan, C. A. Programming of initial steps in bile acid synthesis by breast-feeding vs. formula-feeding in the baboon. Lipids 38:1213-1220, 2003

Updated: 6/21/04