Annette W. Fothergill, MA, MBA, MT(ASCP).
Assistant Professor
Technical Director
Fungus Testing Laboratory
Location: MED, Room 329 E
Phone (voice): 210 567 6074
Fax: (210) 567-4076
E-mail: fothergill@uthscsa.edu

Degrees

1994-97, MBA
1983-87, B.S., University of Texas Health Sciences Center at San Antonio


Description of Research

Our research involves the laboratory evaluation of antifungal agents and evaluation of new diagnostic tests. Activities include in vitro testing of both approved and investigational compounds against a wide-range of clinically significant fungi. Additionally, we participate in clinical trials and evaluate the efficacy of these agents both prior to FDA submission and following submission when seeking approval for expanded indications. The Fungus Testing Laboratory is an international reference laboratory receiving clinical specimens for antifungal susceptibility testing, antifungal drug level determination in serum or other sources and for identification. The laboratory is also appointed as a testing site for the Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards.

Unique Technical and Clinical Research Capabilities/Instrumentation:

The Fungus Testing Laboratory serves as an international reference laboratory for the identification of fungal isolates to the species level, provides in vitro susceptibility testing of both yeasts and moulds, including dimorphic pathogens, and determines antifungal drug levels in body fluids by bioassay, HPLC, and GLC methodologies. Additionally, we serve as a central laboratory for clinical trials of various approved/investigational antifungal agents.


PUBLICATIONS

CD-ROM

Koneman, E., D.A. Sutton, A.W. Fothergjll, M.G. Rinaldi, T. Sun, and S.F. Straus. 2001. LWW’s Organism Central, Lippincott Williams & Wilkins, Hagerstown, MD.


Book Chapter

Smith, LA, A.W. Fothergill, D.A. Sutton, J.L. Harris. 2000. Medically Significant Fungi. Chapter 23. In: Textbook of Diagnostic Microbiology, Second Edition, C. Mahon, G. Manuselis (ed.), Current Medicine.

Books

Sutton, D.A., A.W. Fothergill, and M.G. Rinaldi. 1998. Guide to Clinically Significant Fungi. Williams & Wilkins, Baltimore, MD.


Refereed Papers

*Barchiesi F. Arzeni D. Fothergill AW. Di Francesco LF. Caselli F. Rinaldi MG. Scalise G. In vitro activities of the new antifungal triazole SCH 56592 against common and emerging yeast pathogens. 2000 Antimicrobial Agents & Chemotherapy. 44(1):226-9.

*Jessup C, Reyes G, Fothergill A, McCarthy D, Rinaldi M, Messer S, Pfaller M, Ghannoum M A head-on comparison of the in vitro antifungal activity of conventional and lipid-based amphotericin B: a multicenter study. J Chemother. 2000 Feb;12(1):22-9.

*Kirkpatrick WR, McAtee RK, Fothergill AW, Loebenberg D, Rinaldi MG, Patterson TF Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. Antimicrob Agents Chemother. 2000 Mar;44(3):780-2.

*Yildiran ST, Saracli MA, Fothergill AW, Rinaldi MG In vitro susceptibility of environmental Cryptococcus neoformans variety neoformans isolates from Turkey to six antifungal agents, including SCH56592 and voriconazole. Eur J Clin Microbiol Infect Dis. 2000 Apr;19(4):317-9.

*Perea S, Pennick GJ, Modak A, Fothergill AW, Sutton DA, Sheehan DJ, Rinaldi MG Comparison of high-performance liquid chromatographic and microbiological methods for determination of voriconazole levels in plasma. Antimicrob Agents Chemother. 2000 May;44(5):1209-13.

*Al-Abdely HM, Najvar L, Bocanegra R, Fothergill A, Loebenberg D, Rinaldi MG, Graybill JR SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei"). Antimicrob Agents Chemother. 2000 May;44(5):1159-62.

*Bialek R, Ibricevic A, Aepinus C, Najvar LK, Fothergill AW, Knobloch J, Graybill JR. Detection of Paracoccidioides brasiliensis in tissue samples by a nested PCR assay. J Clin Microbiol. 2000 Aug;38(8):2940-2.

*Bialek R, Ibricevic A, Fothergill A, Begerow D Small subunit ribosomal DNA sequence shows Paracoccidioides brasiliensis closely related to Blastomyces dermatitidis.. J Clin Microbiol. 2000 Sep;38(9):3190-3.

*Kirkpatrick WR, McAtee RK, Fothergill AW, Rinaldi MG, Patterson TF. Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis. Antimicrob Agents Chemother. 2000 Oct;44(10):2865-8.

*Perea S, Fothergill AW, Sutton DA, MG Rinaldi. Comparison of In vitro activities of voriconazole and five established antifungal agents against different species of dermatophytes using a broth macrodilution method... J Clin Microbiol. 2001 Jan;39(1):385-8.

*Redding, SW, CW Bailey, JL Lopez-Ribot, WR Kirkpatrick, AW Fothergill, MG Rinaldi, and TF Patterson. Candida dubliniensis in radiation-induced oropharyngeal candidiasis. Oral Medicine. 2001. June 91(6):659-662.
 

Key Words:
Fungi, mycology, antifungal agents, antifungal susceptibility testing, clinical trials
 

2/8/02