Jaqueline J. Coalson, Ph.D.
Department of Pathology – Mail Code 7750
The University of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio, Texas 78229-3900
1965, Ph.D., University of Oklahoma
1963, M.S., University of Oklahoma
1960, B.S., Oklahoma Baptist University, Cum Laude
DESCRIPTION OF RESEARCH
Over the years, our research group has had access to controlled animal experiments via the adult ARDS baboon and infant BPD baboon models, and to human populations with BPD and ARDS. My current research efforts focus on the injury/repair/recovery processes of baboon infants with severe lung injury. Using morphometric and pulmonary function testing, the sequelae of BPD are determined in the premature baboon initially treated with positive pressure ventilation and hyperoxia for a prolonged period. After development of the disease, animals are weaned, and then studied at specified time intervals. In situ hybridization and immunocytochemical studies of the surfactant apoproteins and several growth hormones are being defined at various post injury time points and compared to expected maturational changes of prenatal lung. Immunocytochemical and quantitative studies examining apoptosis and angiogenesis are being done in human and baboon specimens. All of this data can be compared and contrasted to a large database of comparable information already determined for the adult baboon with a hyperoxic induced ARDS episode.
My primary academic interest is all aspects of pulmonary pathology, especially non-neoplastic pulmonary disease.
Coalson JJ, King RJ, Yang F, Winter V, Whitsett JA, deLemos RA, Seidner SR. SP-A deficiency in primate model of BPD and infection. In situ mRNA and immunostains. Am J Respir Crit Care Med 151:854-898 1995.
Coalson JJ, Winter V, deLemos RA. Decreased alveolarization in baboon survivors with BPD. Am J Respir Crit Care Med 152:640-646, 1995.
Yang, F., Friedrichs, S.E., deGraffenried, L.A., Herbert, D. C., Weaker, F. J., Bowman, B.H., Coalson, J. J. Cellular expression of ceruloplasmin in baboon and mouse lung during development and inflammation. Am J Respir Cell Molecul Biol. 14:161-169, 1996.
Clerch, L.B., Wright, A.E., Coalson, J.J. Lung manganese superoxide dismutase protein expression increases in the baboon model of bronchopulmonary dysplasia and is regulated at a port-transcriptional level. Pediatr. Res. 39:253-258, 1996.