SIDDHARTH G. ADHVARYU, Ph.D., FACMG. Associate Professor and Director, Cytogenetics Laboratory Phone: (210) 567-4021 E-mail: adhvaryu@uthscsa.edu

Degrees

1979  Ph.D., Gujarat University, India.
1973  M.Sc., Gujarat University, India.
1971  B.Sc., Gujarat University, India.


Training - Fellowship:

1986-87 British Council Fellow, Paterson Institute for Cancer Research, Manchester and Royal Marsden Hospital, Sutton, UK.
1994-96 Fellow in Medical Genetics (Clinical Cytogenetics), Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham NC 27710.


Teaching, Service & Research:

I have mentored six Ph.D. students as a major thesis adviser and have accomplished several research projects sponsored by Federal and State agencies. The findings have been published in form of more than 50 papers in leading peer reviewed journals. I have also actively participated in teaching Undergraduate & Graduate students as well as to Fellows and Residents from Departments of Pathology, Pediatrics, Maternal and Fetal Medicine and Medical Oncology.

My major interest is in developing and leading a full-service Clinical and Molecular Cytogenetics Laboratory, with capabilities to provide excellent services to Clinical Geneticists and Medical Oncologists. The full-service laboratory shall provide teaching and training facilities for fellows, residents and students.


Research Interest:

* Use of Fluorescence in-situ hybridization technology in clarifying subtle abnormalities and cryptic translocations in chromosomes from leukemia and lymphoma patients. Also use of FISH in providing useful information in specimens with no mitotic activity.

* Role of Cytogenetic Markers in Cancer Predisposition: Has studied cytogenetic markers in general populations and in cancer patients and immediate family members to derive interesting links between chromosomal markers and incidence of leukemia and solid tumors.

* Application of Cytogenetic Parameters in assessment of Genomic Damage in any personal habit or environmental exposure associated cancers. Standardized and applied a multi-parameter combination to identify extent of genomic damage to the target and non-target tissues in areca nut / tobacco addicted individuals with and without cancer of the oral cavity. The work yielded interesting clues in application of these parameters in identifying individuals more prone to habit associated genomic damage.


SELECTED LIST OF PUBLICATIONS:

1. Qumsiyeh M.B., Adhvaryu S.G., Ahmed, MN and Teebi, AS
Cytogenetics. (Chapter 2) In: Textbook of Clinical Pediatrics
Eds: Elzouki, Harfi and Nazer, pp 20-32, 2001.

2. Adhvaryu S.G., Peters-Brown T., Livingston E. and Qumsiyeh M.B.
Familial supernumerary marker chromosome evolution through three
generations.
Prenatal Diagnosis 18: 178-181, 1998.

3. Quimseyah M.B., Adhvaryu S.G., Peters-Brown T., Kath S. and Kay H.
Discrepancies in cytogenetic findings in chorionic villi.
The Journal of Maternal-Fetal Medicine 6(6): 351-355, 1997.

4. Trivedi A.H., Roy S.K., Jaju R.J., Patel R.K., Adhvaryu S.G., Balar D.B.
Urine of tobacco/areca nut chewers causes genomic damage in Chinese
hamster ovary cells.
Carcinogenesis, 16, 205-208, 1995.

5. Trivedi AH, Bakshi SR, Jaju RJ, Dave BJ, Adhvaryu S.G., Balar DB
Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients.
Anticancer Research, 15 : 2589-2592, 1995.

6. Trivedi A.H., Patel R.K., Rawal U.M., Adhvaryu S.G., Balar D.B.
Evaluation of chemopreventive effects of betel leaf on the genotoxicity of pan masala.
Neoplasma, 41, 175-179, 1994.

7. Patel R.K., Trivedi A.H., Jaju R.J., Adhvaryu S.G., Balar D.B.
Pan masala--a genotoxic menace.
Mutation Research, 320 : 245-249, 1994.

8. Kayal J.J., Trivedi A.H., Dave B.J., Nair U.J., Bhide S.V., Adhvaryu S.G.
Incidence of micronuclei in oral mucosa of tobacco products singly or in various combinations.
Mutagenesis, 8: 31-33, 1993.

9. Trivedi AH, Dave BJ, Adhvaryu S.G.
Genotoxic effects of nicotine in combination with arecoline on CHO cells.
Cancer Letters, 74 : 105-110, 1993.

10. Trivedi A.H., Dave B.J., Adhvaryu S.G.
Monitoring of smokeless tobacco consumers using cytogenetic endpoints.
Anticancer Research, 13, 2245-2249, 1993.

11. Dave B.J., Trivedi A.H., Adhvaryu S.G.
In vitro genotoxic effects of areca nut extracts and arecoline.
Journal of Cancer Research in Clinical Oncology, 118: 283-288, 1992.

12. Dave B.J., Trivedi A.H., Adhvaryu S.G.
Role of areca nut consumption in causation of oral cancer: A cytogenetic assessment.
Cancer, 70: 1017-1023, 1992.

13. Dave B.J., Trivedi A.H., Adhvaryu S.G.
Variations in centromeric heterochromatin among patients with oral premalignant and malignant diseases.
International Journal of Cancer, 48: 386-389, 1991.

14. Adhvaryu S.G., Dave B.J., Trivedi A.H.
Cytogenetic surveillance of tobacco-areca nut chewers, including patients with oral cancer and premalignant conditions.
Mutation Research, 261: 41-49, 1991.

15. Patel P.S., Adhvaryu S.G., Baxi B.R.
Tumor markers in leukemia: evaluation of serum levels of different forms of sialic acid, Regan isoenzyme and lactate dehydrogenase.
Int J Biol Markers, 6 : 177-182, 1991.

16. Dave B.J., Trivedi A.H., Adhvaryu S.G.
Cytogenetic studies reveal increased genomic damage among 'pan masala' consumers. Mutagenesis, 6 :159-163, 1991.

17. Baxi B.R., Patel P.S., Adhvaryu S.G., Dayal P.K.
Usefulness of serum glycoconjugates in precancerous and cancerous diseases of the oral cavity.
Cancer, 67 : 135-140, 1991.

18. Adhvaryu S.G., Rawal U.M.
C-band heterochromatin variants in individuals with neoplastic disorders: carcinoma of breast and ovary.
Neoplasma, 38 : 379-384, 1991.